高雄醫學大學天然物藥庫暨高通量篩選核心
使用者之文章發表
    2022
  • Yu, TJ; Yen, CY; Cheng, YB; Yen, CH; Jeng, JH; Tang, JY; Chang, HW. Physapruin A Enhances DNA Damage and Inhibits DNA Repair to Suppress Oral Cancer Cell Proliferation. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2022 AUG 23(16)
  • Yang, CW; Chien, TM; Yen, CH; Wu, WJ; Sheu, JH; Chang, HW. Antibladder Cancer Effects of Excavatolide C by Inducing Oxidative Stress, Apoptosis, and DNA Damage In Vitro. PHARMACEUTICALS. 2022 AUG 15(8)
  • Tai, CJ; Ahmed, AF; Chao, CH; Yen, CH; Hwang, TL; Chang, FR; Huang, YSM; Sheu, JH. Spongenolactones A-C, Bioactive 5,5,6,6,5-Pentacyclic Spongian Diterpenes from the Red Sea Sponge Spongia sp. MARINE DRUGS. 2022 AUG 20(8)
  • Yu, ZJ; Shiau, JP; Tang, JY; Yen, CH; Hou, MF; Cheng, YB; Shu, CW; Chang, HW. Physapruin A Induces Reactive Oxygen Species to Trigger Cytoprotective Autophagy of Breast Cancer Cells. ANTIOXIDANTS. 2022 JUL 11(7)
  • Hsu, SK; Chu, YH; Syue, WJ; Lin, HYH; Chang, WT; Chen, JYF; Wu, CY; Yen, CH; Cheng, KC; Chiu, CC. The Role of Nonapoptotic Programmed Cell Death - Ferroptosis, Necroptosis, and Pyroptosis - in Pancreatic Ductal Adenocarcinoma Treatment. FRONTIERS IN ONCOLOGY. 2022 MAY 12
  • Tai, CJ; Ahmed, AF; Chao, CH; Yen, CH; Hwang, TL; Chang, FR; Huang, YM; Sheu, JH. The Chemically Highly Diversified Metabolites from the Red Sea Marine Sponge Spongia sp. MARINE DRUGS. 2022 APR 20(4)
  • Yu, TJ; Tang, JY; Shiau, JP; Hou, MF; Yen, CH; Ou-Yang, F; Chen, CY; Chang, HW. Gingerenone A Induces Antiproliferation and Senescence of Breast Cancer Cells. ANTIOXIDANTS. 2022 MAR 11(3)
  • Chen, YC; Yang, CW; Chan, TF; Farooqi, AA; Chang, HS; Yen, CH; Huang, MY; Chang, HW. Cryptocaryone Promotes ROS-Dependent Antiproliferation and Apoptosis in Ovarian Cancer Cells. CELLS. 2022 FEB 11(4)
  • Hu, HC; Yu, SY; Hung, XS; Su, CH; Yang, YL; Wei, CK; Cheng, YB; Wu, YC; Yen, CH; Hwang, TL; Chen, SL; Szatmari, I; Hunyadi, A; Tsai, YH; Chang, FR. Composition decipherment of Ficus pumila var. awkeotsang and its potential on COVID-19 symptom amelioration and in silico prediction of SARS-CoV-2 interference. JOURNAL OF FOOD AND DRUG ANALYSIS. 2022 30(3)
  • Mykhailenko, O; Petrikaite, V; Korinek, M; Chang, FR; El-Shazly, M; Yen, CH; Bezruk, I; Chen, BH; Hsieh, CF; Lytkin, D; Ivanauskas, L; Georgiyants, V; Hwang, TL. Pharmacological Potential and Chemical Composition of Crocus sativus Leaf Extracts. MOLECULES. 2022 JAN 27(1)
  • 2021
  • Nguyen, HM; Nguyen, NYT; Chau, NTN; Nguyen, ABT; Tran, VT; Hoang, V; Le, TM; Wang, HC; Yen, CH. Bioassay-Guided Discovery of Potential Partial Extracts with Cytotoxic Effects on Liver Cancer Cells from Vietnamese Medicinal Herbs. PROCESSES. 2021 NOV 9(11)
  • Korinek, M; Handoussa, H; Tsai, YH; Chen, YY; Chen, MH; Chiou, ZW; Fang, Y; Chang, FR; Yen, CH; Hsieh, CF; Chen, BH; El-Shazly, M; Hwang, TL. Anti-Inflammatory and Antimicrobial Volatile Oils: Fennel and Cumin Inhibit Neutrophilic Inflammation via Regulating Calcium and MAPKs. FRONTIERS IN PHARMACOLOGY. 2021 OCT 12
  • Hsu, SK; Cheng, KC; Mgbeahuruike, MO; Lin, YH; Wu, CY; Wang, HMD; Yen, CH; Chiu, CC; Sheu, SJ. New Insight into the Effects of Metformin on Diabetic Retinopathy, Aging and Cancer: Nonapoptotic Cell Death, Immunosuppression, and Effects beyond the AMPK Pathway. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2021 SEP 22(17)
  • Mykhailenko, O; Petrikaite, V; Korinek, M; El-Shazly, M; Chen, BH; Yen, CH; Hsieh, CF; Bezruk, I; Dabrisiute, A; Ivanauskas, L; Georgiyants, V; Hwang, TL. Bio-guided bioactive profiling and HPLC-DAD fingerprinting of Ukrainian saffron (Crocus sativus stigmas): moving from correlation toward causation. BMC COMPLEMENTARY MEDICINE AND THERAPIES. 2021 JUL 21(1)
  • Chien, TM; Wu, KH; Chuang, YT; Yeh, YC; Wang, HR; Yeh, BW; Yen, CH; Yu, TJ; Wu, WJ; Chang, HW. Withaferin a Triggers Apoptosis and DNA Damage in Bladder Cancer J82 Cells through Oxidative Stress. ANTIOXIDANTS. 2021 JUL 10(7)
  • Kant, R; Yang, MH; Tseng, CH; Yen, CH; Li, WY; Tyan, YC; Chen, M; Tzeng, CC; Chen, WC; You, KT; Wang, WC; Chen, YL; Chen, YMA. Discovery of an Orally Efficacious MYC Inhibitor for Liver Cancer Using a GNMT-Based High-Throughput Screening System and Structure-Activity Relationship Analysis. JOURNAL OF MEDICINAL CHEMISTRY. 2021 JUL 64(13)
  • Yu, TJ; Cheng, YB; Lin, LC; Tsai, YH; Yao, BY; Tang, JY; Chang, FR; Yen, CH; Ou-Yang, F; Chang, HW. Physalis peruviana-Derived Physapruin A (PHA) Inhibits Breast Cancer Cell Proliferation and Induces Oxidative-Stress-Mediated Apoptosis and DNA Damage. ANTIOXIDANTS. 2021 MAR 10(3)
  • Wang, SC; Li, CY; Chang, WT; Cheng, WC; Yen, CH; Tu, WY; Lin, ZY; Lin, CC; Yeh, ML; Huang, CF; Huang, JF; Dai, CY; Chuang, WL; Chen, YL; Yu, ML. Exosome-derived differentiation antagonizing non-protein coding RNA with risk of hepatitis C virus-related hepatocellular carcinoma recurrence. LIVER INTERNATIONAL. 2021 MAY 41(5)
  • Hsu, SK; Li, CY; Lin, IL; Syue, WJ; Chen, YF; Cheng, KC; Teng, YN; Lin, YH; Yen, CH; Chiu, CC. Inflammation-related pyroptosis, a novel programmed cell death pathway, and its crosstalk with immune therapy in cancer treatment. THERANOSTICS. 2021 11(18)
  • 2020
  • Mykhailenko, O; Korinek, M; Ivanauskas, L; Bezruk, I; Myhal, A; Petrikaite, V; El-Shazly, M; Lin, GH; Lin, CY; Yen, CH; Chen, BH; Georgiyants, V; Hwang, TL. Qualitative and Quantitative Analysis of Ukrainian Iris Species: A Fresh Look on Their Antioxidant Content and Biological Activities. MOLECULES. 2020 OCT 25(19)
  • Hu, HC; Li, CY; Tsai, YH; Yang, DY; Wu, YC; Hwang, TL; Chen, SL; Fulop, F; Hunyadi, A; Yen, CH; Cheng, YB; Chang, FR. Secondary Metabolites and Bioactivities of Aspergillus ochraceopetaliformis Isolated from Anthurium brownii. ACS OMEGA. 2020 AUG 5(33)
  • Wu, HC; Cheng, MJ; Yen, CH; Chen, YMA; Chen, YS; Chen, IS; Chang, HS. Chemical Constituents with GNMT-Promoter-Enhancing and NRF2-Reduction Activities from Taiwan Agarwood Excoecaria formosana. MOLECULES. 2020 APR 25(7)
  • Yang, WS; Lin, TY; Chang, L; Yeh, WW; Huang, SC; Chen, TY; Hsieh, YT; Chen, ST; Li, WC; Pan, CC; Campbell, M; Yen, CH; Chen, YMA; Chang, PC. HIV-1 Tat Interacts with a Kaposi's Sarcoma-Associated Herpesvirus Reactivation-Upregulated Antiangiogenic Long Noncoding RNA, LINC00313, and Antagonizes Its Function. JOURNAL OF VIROLOGY. 2020 FEB 94(3)
  • 2019
  • Huang, JW; Chen, CJ; Yen, CH; Chen, YMA; Liu, YP. Loss of Glycine N-Methyltransferase Associates with Angiopoietin-Like Protein 8 Expression in High Fat-Diet-Fed Mice. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2019 SEP 20(17)
  • Tang, JY; Peng, SY; Cheng, YB; Wang, CL; Farooqi, AA; Yu, TJ; Hou, MF; Wang, SC; Yen, CH; Chan, LP; Fu, OY; Chang, HW. Ethyl acetate extract of Nepenthes adrianii x clipeata induces antiproliferation, apoptosis, and DNA damage against oral cancer cells through oxidative stress. ENVIRONMENTAL TOXICOLOGY. 2019 AUG 34(8)
  • Tang, JY; Li, LJ; Fu, OY; Wang, CL; Shu, CW; Wu, KH; Wang, HR; Yen, CH; Cheng, YB; Chang, HW. Ethyl Acetate Extract of Nepenthes ventricosa x maxima Exerts Preferential Killing to Oral Cancer Cells. DNA AND CELL BIOLOGY. 2019 AUG 38(8)
核心設施研發
    2022
  • Wang, SH; Chen, YS; Lai, KH; Lu, CK; Chang, HS; Wu, HC; Yen, FL; Chen, LY; Lee, JC; Yen, CH. Prinsepiae Nux Extract Activates NRF2 Activity and Protects UVB-Induced Damage in Keratinocyte. ANTIOXIDANTS. 2022 SEP 11(9)
  • Tseeleesuren, D; Hsiao, HH; Kant, R; Huang, YC; Tu, HP; Lai, CC; Huang, SF; Yen, CH. The Expression and Prognostic Value of Cancer Stem Cell Markers, NRF2, and Its Target Genes in TAE/TACE-Treated Hepatocellular Carcinoma. MEDICINA-LITHUANIA. 2022 FEB 58(2)
  • 2021
  • Fu, H; Yen, FL; Huang, PH; Yang, CY; Yen, CH. Oleanolic Acid Nanofibers Attenuated Particulate Matter-Induced Oxidative Stress in Keratinocytes. ANTIOXIDANTS. 2021 SEP 10(9)
  • Chen, YS; Chang, HS; Hsiao, HH; Chen, YF; Kuo, YP; Yen, FL; Yen, CH. Identification of Beilschmiedia tsangii Root Extract as a Liver Cancer Cell-Normal Keratinocyte Dual-Selective NRF2 Regulator. ANTIOXIDANTS. 2021 APR 10(4)
  • 2020
  • Yen, CH; Hsu, CM; Hsiao, SY; Hsiao, HH. Pathogenic Mechanisms of Myeloma Bone Disease and Possible Roles for NRF2. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2020 SEP 21(18)
  • Kant, R; Lu, CK; Nguyen, HM; Hsiao, HH; Chen, CJ; Hsiao, HP; Lin, KJ; Fang, CC; Yen, CH. 1,2,3,4,6 penta-O-galloyl-beta-D-glucose ameliorates high-fat diet-induced nonalcoholic fatty liver disease and maintains the expression of genes involved in lipid homeostasis in mice. BIOMEDICINE & PHARMACOTHERAPY. 2020 SEP 129
  • 2019
  • Yang, MH; Liao, CC; Hung, JH; Lai, XT; Yen, CH; Chen, YMA. Utilizing proteomic approach to identify nuclear translocation related serine kinase phosphorylation site of GNMT as downstream effector for benzo[a]pyrene. JOURNAL OF FOOD AND DRUG ANALYSIS. 2019 APR 27(2)
合作開發
    2022
  • Hsiao, HH; Liu, YC; Wang, HC; Du, JS; Tang, SH; Yeh, TJ; Hsieh, CY; Gau, YC; Ke, YL; Chuang, TM; Hsiao, CE; Yen, CH; Cho, SF; Hsiao, SY; Chiou, SS; Lin, SY; Hsu, CM; Lu, PL. Comparison of a novel lateral-flow device to galactomannan assay at different time periods for detections of invasive aspergillosis. JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION. 2022 OCT 121(10)
  • Liu, WT; Hsu, YY; Tang, JY; Cheng, YB; Chuang, YT; Jeng, JH; Yen, CH; Chang, HW. Methanol Extract of Commelina Plant Inhibits Oral Cancer Cell Proliferation. ANTIOXIDANTS. 2022 SEP 11(9)
  • Hsu, CM; Yen, CH; Wang, SC; Liu, YC; Huang, CT; Wang, MH; Chuang, TM; Ke, YL; Yeh, TJ; Gau, YC; Du, JS; Wang, HC; Cho, SF; Tsai, YH; Hsiao, CE; Hsiao, SY; Hsiao, HH. Emodin Ameliorates the Efficacy of Carfilzomib in Multiple Myeloma Cells via Apoptosis and Autophagy. BIOMEDICINES. 2022 JUL 10(7)
  • Chang, YH; Yen, CH; Lai, CC; Lai, HY; Hung, HY. Discovery of 5,7-Dimethoxy-2-(3,4,5-trimethoxyphenoxy)-chromen-4-one with Lipid Lowering Effects in Hepatocytes. PHARMACEUTICALS. 2022 APR 15(4)
  • 2021
  • Du, JS; Yen, CH; Hsu, CM; Hsiao, HH. Management of Myeloma Bone Lesions. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2021 APR 22(7)
  • Huang, SW; Miller, SO; Yen, CH; Wang, SF. Impact of Genetic Variability in ACE2 Expression on the Evolutionary Dynamics of SARS-CoV-2 Spike D614G Mutation. GENES. 2021 JAN 12(1)
  • 2020
  • Kao, YT; Chen, YS; Tang, KW; Lee, JC; Tseng, CH; Tzeng, CC; Yen, CH; Chen, YL. Discovery of 4-Anilinoquinolinylchalcone Derivatives as Potential NRF2 Activators. MOLECULES. 2020 JUL 25(14)
  • 2019
  • Yang, MH; Yen, CH; Chen, YF; Fang, CC; Li, CH; Lee, KJ; Lin, YH; Weng, CH; Liu, TT; Huang, SF; Teh, BT; Chen, YMA. Somatic mutations of PREX2 gene in patients with hepatocellular carcinoma. SCIENTIFIC REPORTS. 2019 FEB 9
  • Kant, R; Yen, CH; Hung, JH; Lu, CK; Tung, CY; Chang, PC; Chen, YH; Tyan, YC; Chen, YMA. Induction of GNMT by 1,2,3,4,6-penta-O-galloyl-beta-D-glucopyranoside through proteasome-independent MYC downregulation in hepatocellular carcinoma. SCIENTIFIC REPORTS. 2019 FEB 9